What are Piperazines TFMPP (Trifluoromethylphenylpiperazine)?
Piperazines are a broad class of chemical compounds that mimic the effects of Ecstasy. They were produced as a legal alternative to Ecstasy (though have since been classified as Class C drugs) and have been found as a cutting agent in some Ecstasy pills. The best-known Piperazines are BZP, TFMPP, DBZP, and MCPP.
TFMPP is a piperazine derivative and serotonin receptor agonist. It is often administered as a hydrochloride salt . It undergoes extensive biotransformation via p-hydroxylation, piperazine ring-opening, side-chain oxidation, and conjugation. In addition to the parent compound (free and unchanged), its metabolites include conjugated hydroxyl(OH)-TFMPP, N-(3-trifluoromethylphenyl) ehtylenediamine (TFMPED), 3-trifluormethylaniline (TFMA), and the p-hydroxylation products (OH-TFMPED, OH-TFMA) [1, 4]. Users describe the effect of TFMPP as similar to those of MDMA and lysergic acid diethylamide or LSD and include euphoria, mild central nervous system stimulation, and visual distortion in addition to the previously mentioned effects. As with BZP users can experience nausea, vomiting, dizziness, bruxism, mydriasis, and tachycardia.
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The stimulant effects of Piperazines are similar to MDMA (Ecstasy) but dose for dose they are not as potent. Effects can last for 6 – 8 hours and include feelings of euphoria, of being alert, alive, and full of energy, decreased appetite, and sleeplessness.
DRUG FORM & METHOD OF USE:
Piperazine derivatives are usually found as either tablets or capsules, but loose powders also occur. The tablets often carry logos similar to those seen on ‘ecstasy’ tablets. They are taken orally.
HEALTH RISKS (long term) which includes withdrawal & tolerance:
Taking Piperazines does involve risks. Users often suffer a hangover-like reaction that can last for up to 24 hours. Agitation, Vomiting, Stomach pain, fits, irregular Heart rhythms, Diarrhoea, Allergic reactions, and Fever have been reported. As stimulant drugs, Piperazines are particularly risky if taken by anyone suffering from high blood pressure or a heart condition. And you may not know that you have a pre-existing heart condition. Perfectly healthy young people can have a fit or Heart Attack after taking stimulant drugs. In rare cases, users may suffer from ‘Serotonin Syndrome’. It can cause High Blood pressure and may be fatal and also it is habit-forming.
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