Description of Oxycodone 80 mg
Oxycodone 80 mg is a semisynthetic derivative of codeine that acts as a narcotic analgesic more potent and addicting than codeine. An extended-release (ER) form of oxycodone (Xtampza ER) was approved for the management of daily, around-the-clock pain management in April 2016.
Uses of Oxycodone OC 80mg:
Oxycodone OC 80mg is used to relieve moderate to severe persistent pain when other forms of treatment have not been effective.
It contains the active ingredient oxycodone hydrochloride.
Oxycodone OC 80 mg hydrochloride belongs to a class of drugs known as opioid analgesics.
Opioid analgesics such as oxycodone hydrochloride have been used to treat pain for many years. As with all strong painkillers, your body may become used to you taking Oxycodone OC 80mg tablets. Taking it may result in physical dependence. Physical dependence means that you may experience withdrawal symptoms if you stop taking oxycodone suddenly, so it is important to take it exactly as directed by your doctor.
There is not enough information to recommend the use of this medicine for children under the age of 12 years.
This medicine is available only with a doctor’s prescription
Oxycodone, a semisynthetic opiate agonist derived from the opioid alkaloid, thebaine, is similar to other phenanthrene derivatives such as hydrocodone and morphine. Oxycodone is available in combination with aspirin or acetaminophen to control pain and restless leg and Tourette syndromes.
Mechanism of action:
Oxycodone acts as a weak agonist at mu, kappa, and delta-opioid receptors within the central nervous system (CNS). Oxycodone primarily affects mu-type opioid receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. The binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as oxycodone also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (kappa-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (mu and delta receptor agonist). This results in hyperpolarization and also reduced neuronal excitability.
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