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Generic Dyanavel XR Amphetamine Extended-release Oral Suspension
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This is extended-release oral suspension, a CNS stimulant is an extended-release liquid formulation containing a 3.2 to 1 ratio of d- to l-amphetamine.
Each 1 mL of contains 2.5 mg of amphetamine which is the same as the amount of amphetamine (base equivalent) found in a 4 mg strength amphetamine mixed salts product.
DYANAVEL XR (amphetamine) Structural Formula Illustration
This medicine utilizes an ion exchange resin where the drug is bound to the resin (sodium polystyrene sulfonate) through an ionic binding reaction. It contains immediate-release and extended-release components. The extended-release component is coated with an aqueous, also pH-independent polymer. After drug release, the ion-exchange resin is excreted in the feces.
Inactive Ingredients: anhydrous citric acid, bubblegum flavor, glycerin, methylparaben, modified food starch, polysorbate 80, povidone, polyvinyl acetate, propylparaben, sodium lauryl sulfate, sodium polystyrene sulfonate, sucralose, triacetin, and also xanthan gum.
DYANAVEL XR is a central nervous system (CNS) stimulant indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) [see Clinical Studies].
DOSAGE AND ADMINISTRATION of Dyanavel XR (amphetamine) for ADHD
Important Information Prior To Initiating Treatment
Prior to treating children, adolescents, and adults with CNS stimulants, including DYANAVEL XR, assess for the presence of cardiac disease (i.e., perform a careful history, family history of sudden death or ventricular arrhythmia, and physical exam) [see WARNINGS AND PRECAUTIONS].
Assess the risk of abuse prior to prescribing, and monitor for signs of abuse and dependence while on therapy. Maintain careful prescription records, educate patients about abuse, monitor for signs of abuse and overdose, and periodically re-evaluate the need for DYANAVEL XR use [see PRECAUTIONS, and Drug Abuse and Dependence].
General Dosing Information
DYANAVEL XR should be orally administered once daily in the morning with or without food. The dose should be individualized according to the needs and responses of the patient. Before administering the dose, shake the bottle.
In children 6 years of age and older, start with 2.5 mg or 5 mg once daily in the morning. The dose may be increased in increments of 2.5 mg to 10 mg per day every 4 to 7 days up to a maximum dose of 20 mg per day.
Pharmacological treatment of ADHD may be needed for extended periods. Healthcare providers should periodically re-evaluate the long-term use, and also adjust dosage as needed.
Dosage Forms And Strengths
Extended-release oral suspension contains 2.5 mg amphetamine base per mL.
DYANAVEL XR (amphetamine) extended-release oral suspension, the concentration is 2.5 mg/mL amphetamine base and is supplied as light beige to tan viscous suspension with bubblegum flavor in bottles of 464 mL (NDC 27808-102-01).
Storage And Handling
Dispense in a tight container with a child-resistant closure.
Store at 20° to 25°C (68° to 77°F); excursions permitted from 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature]. So, the pharmacist should provide an oral dosing syringe or other suitable measuring devices.